Mmekọrịta dị n'etiti Hormone uto na ọrịa shuga: ikpughe mmekọrịta dị mgbagwoju anya

Okwu mmalite: Mmekọrịta dị n'etiti hormone na-eto eto (GH) na ọrịa shuga abụwo isiokwu nke mmasị sayensị. Ọ bụ ezie na GH bụ isi mara maka ọrụ ya na uto na mmepe, ọ na-arụkwa ọrụ dị mkpa na metabolism glucose. Edemede a bu n'obi inyocha mmekọrịta dị mgbagwoju anya n'etiti GH na ọrịa shuga, na-eme ka ìhè dị na mmetụta GH na mmetụta insulin, ụkpụrụ glucose na mmepe nke ọrịa shuga.

Ịghọta Hormone Growth: GH, nke a makwaara dị ka somatotropin, bụ hormone nke pituitary gland zoro ezo. Isi ọrụ ya bụ ịkwalite uto n'oge nwata na oge uto. Otú ọ dị, GH na-anọgide na-etinye mmetụta ya na anụ ahụ na akụkụ dị iche iche n'oge ọ bụ okenye. GH na-arụ ọrụ na anụ ahụ ezubere iche, na-akwalite njikọ protein, na-akpali nkewa cell, na-achịkwa metabolism.

GH na Insulin Sensitivity: Otu n'ime njikọ dị n'etiti GH na ọrịa shuga bụ mmetụta ha na mmetụta insulin. Egosiputara GH nwere ma insulin-sensitizing na insulin-antagonistic, dabere n'ihe gbara ya gburugburu. N'ime ndị mmadụ nwere metabolism glucose nkịtị, GH na-eme ka mmetụta insulin dịkwuo elu, na-enye ohere maka nnabata glucose na-arụ ọrụ nke ọma na sel. Otú ọ dị, n'ọnọdụ nke oke GH, dị ka acromegaly, GH nwere ike imebi mmetụta insulin, na-eduga n'ịkwụsị insulin na ihe ize ndụ nke ịmalite ịmalite ọrịa shuga.

GH na Glucose Regulation: GH na-emetụtakwa ụkpụrụ glucose site na-akpali gluconeogenesis, usoro nke imeju na-emepụta glucose site na isi mmalite ndị na-abụghị carbohydrate. Nke a nwere ike ibute mmụba glucose ọbara, ọkachasị n'oge ibu ọnụ ma ọ bụ nrụgide. GH na-egbochikwa nnabata glucose n'ime anụ ahụ dị n'akụkụ, na-enye aka n'ihu na ọkwa glucose ọbara dị elu. Otú ọ dị, n'ime ndị nwere ụkọ GH, a hụla nnabata glucose na-adịghị mma na ihe ize ndụ dị ukwuu nke ọrịa shuga, na-atụ aro na ụkọ GH nwekwara ike ịrụ ọrụ na glucose dysregulation.

GH na Ọrịa shuga 1dị 1: Ọrịa shuga Ụdị 1 bụ ọrịa autoimmune nke e ji emebi mkpụrụ ndụ beta na-emepụta insulin na pancreas. Nnyocha egosiwo na ndị nwere ụdị ọrịa shuga 1 na-egosipụtakarị mbelata GH secretion. Enweghị ụkọ GH a nwere ike itinye aka n'ịkwalata uto na igbu oge oge ntozu n'ime ụmụaka nwere ụdị ọrịa shuga XNUMX. Ọzọkwa, egosipụtara ọgwụgwọ nnọchi GH iji meziwanye uto na njikwa metabolic na ndị a.

GH na ọrịa shuga 2dị 2: ụdị ọrịa shuga 2 bụ nke a na-eji nguzogide insulin na njikwa glucose na-adịghị mma. GH ngafe, dị ka a na-ahụ na acromegaly, ejikọtawo na ihe ize ndụ dị ukwuu nke ịmalite ịrịa ọrịa shuga XNUMX. Usoro ndị dị n'okpuru njikọ a dị mgbagwoju anya na multifactorial. Mfefe GH nwere ike ibute nguzogide insulin site na itinye aka na ụzọ mgbaàmà insulin na ịkwalite lipolysis, na-ebute mmụba nke abụba abụba n'efu, nke na-enye aka n'ịkwụsị insulin. Na mgbakwunye, ngafe GH nwere ike imebi ọrụ mkpụrụ ndụ beta nke pancreatic, na-eduga n'inwe insulin ezughi oke.

Mmetụta ọgwụgwọ: Nyere mmekọrịta dị mgbagwoju anya n'etiti GH na ọrịa shuga, ọ dị mkpa ịtụle ọgwụgwọ ọgwụgwọ. N'ime ndị mmadụ nwere ụkọ GH, ọgwụgwọ nnọchi GH nwere ike ịba uru n'ịkwalite nhazi glucose yana mmetụta insulin. N'aka nke ọzọ, na ọnọdụ nke oke GH, dị ka acromegaly, usoro ọgwụgwọ na-achọ ibelata ọkwa GH ma weghachi mmetụta insulin. Na mgbakwunye, nyocha na-apụta na-enyocha ike iji ndị na-emegide ndị na-anabata GH na njikwa insulin resistance na ụdị ọrịa shuga 2.

Mmechi: Mmekọrịta dị n'etiti GH na ọrịa shuga dị mgbagwoju anya na ọtụtụ akụkụ. GH na-emetụta mmetụta insulin, nhazi glucose, yana mmepe nke ụdị 1 na ụdị ọrịa shuga 2. Ịghọta mkparịta ụka a dị oke mkpa maka ịkwalite usoro ọgwụgwọ n'ime ndị mmadụ nwere ụkọ GH ma ọ bụ karịa. Ọ dị mkpa nyocha ọzọ iji kpughee usoro mgbagwoju anya dị n'okpuru mmekọrịta a ma mepụta ihe ndị ezubere iche iji meziwanye metabolism nke glucose ma gbochie mmepe nke ọrịa shuga n'ime ndị nwere ike ịdaba.